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Anadrol is estrogenic, unlike superdrol, thus causing significant amounts of weight gain in the form of lean muscle and water retentionas water is used in the formation of estrogenic metabolites. One study showed an increase in fat mass in animals treated with 0.5% diclofenac, or 1.5%-2.5% diclofenac, both in the oral and topical areas. Carcinogenicity The carcinogenicity is low, with only the animal data supporting the efficacy for the cancer prevention in human trials. Tolerance and safety It was found that chronic use of diclofenac did not cause any changes in the plasma metabolite profile. Diclofenac was not approved by the FDA for use in pregnant and lactating women. Adderall Diclofenac and derivatives were not effective as an adjuvant for stimulant related headaches in humans. Carcinogenicity There is concern regarding the carcinogenicity of diclofenac when taken under a medical supervision. No toxicological data were available for diclofenac when studied in lab animals. Tolerance and safety It was found that chronic use of diclofenac, when taken under a medical supervision, did not cause any changes in the plasma metabolite profile. Tolerance and safety No toxicological data were available for diclofenac when studied in lab animals. Glycemic index Carcinogenicity The only carcinogenicity data available for diclofenac was of an oral carcinogenicity study in rats. It included 2–20 mg/kg (oral administration) for 7 days, which resulted in a significant increase in the incidence of lymphopenia on day 7. It was also concluded that no dose or dose range had an influence on adverse effect profile or carcinogenicity. When diclofenac is administered to a population of rodents it is known to increase the incidence of lymphopenia. It was found that chronic administration of diclofenac at a dosage of 0.05 to 0.1 mg/kg/day for 5 days did not cause any appreciable increase in the incidence of lymphopenia. Carcinogenicity The oral carcinogenicity studies with diclofenac were conducted in rabbits. The data reported here did not provide adequate data to establish the carcinogenicity Related Article: